Monoclonal Antibodies and Polyclonal Antibodies: A Brief Comparison

It is called an immunoglobulin that is used for neutralization of the foreign pathogens like viruses, bacteria or any foreign bodies invade the blood. When antibodies produced from immunized animals against certain antigen will produce what is called polyclonal antibodies (PAbs) which are mixture of different antibodies produced by many different B cell clones that identify different epitopes (Antibodies binding sites) on the similar antigen like anti-tetanic serum [1]. On the other hand, monoclonal antibodies are homogeneous antibody preparations from a single antibody secreting B cell and able to bind with one exclusive epitope. Each single antibody in a polyclonal pool is theoretically a monoclonal antibody; however, the process by which B-cell clone isolation and fusion to myeloma immortalized cell line to produce hybridoma secreting huge amounts of identical antibody specific to unique epitope [1,2].